Conventional medicines find Malaria difficult to treat as the parasites responsible become more resistant

About two decades ago it was thought that malaria had been eradicated from India. However, recently, there has been a resurgence of this disease.

Malaria spreads through a mosquito bite (female anopheles) and the common causative organisms in India is plasmodium vivax and p falciparum (malaria parasite). Malaria caused by this parasite does not always cause any permanent damage. It is characterized by fever every third day, followed by rigor or shivering and accompanied by headache and muscle pain. In some cases, there may be enlargement of the liver and spleen. The final diagnosis can be made by examining the blood for the presence of the parasite. Lately a resistant strain of plasmodium vivax and p falciparum has erupted in some areas of India. This has made the treatment more difficult since it is resistant to the usual anti-malarial drugs.

How Does the Disease Progress? The malarial parasite gets injected into the bloodstream by the bite of the female anopheles mosquito and reaches the liver where it multiplies. The baby parasites are released from the liver into the bloodstream, where they enter the red blood cells (RBCs) or return to the liver. Those which enter the RBCs, grow and further multiply. This leads to distension and bursting of RBCs and releasing the toxic metabolites of these multiplied parasites, resulting in rigour and fever. The released parasite may re-enter into other RBCs to repeat the cycle of growth and multliplication, causing another attack of rigonr and fever. This new cycle in RBCs takes about 48 hours and account for the occurrence of fever and rigour every third day. Those who enter the liver may be responsible for continuance of the disease; it takes about two weeks’ time to complete the multiplication cycle. The parasites can be attacked in the RBCs or in the liver.

Drugs that are generally used for malaria

Chloroquine

This is the drug of choice for benign tertian malaria which is usually caused by plasmodium vivax. The oral dose is 600 mg twice of chloroquine (base), followed after 6 hours by 300 mg, then 150mg twise daily, for the next two days. The other drug of this group is amodiaquine. However, some stains of P. falciparum are resistant to chloroquine. In such a situation, quinine is given intravenously. Chloroquine may cause nausea, vomiting and stomach pain. It can be given during pregnancy.

Mefloquine

It is used for treating an acute attack and curing malaria due to resistant strains of parasites. It should be kept reserved for only these patients of malaria, since its misuse may result in the development of mefloquine-resistant strains of the parasites. It is taken in a single dose of 1.5g.

Adverse Effects: Adverse effects of mefloquine are seen in about 1 % patients. These includes irritation in the stomach, fatigue, neurological symptoms in the form of headache, dizziness, visual disturbances, vertigo, tinnitus, insomnia, restlessness, anxiety psychosis, or seizures. It can produce heart-rate irregularities when given along with digoxin, anti-depressants and propranolol.

By: Franchis

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Malaria is very common throughout the world. In the United States, the main risk is to persons traveling to tropical and subtropical countries where malaria is a problem.

There are four different types of malaria caused by four related parasites.

The most deadly type occurs in Africa south of the Sahara Desert. The symptoms characteristic of malaria include fever, chills, muscle aches, and headache. Cycles of chills, fever, and sweating that recur every 1, 2 or 3 days are typical.

There can sometimes be vomiting, diarrhoea, coughing and yellowing (jaundice) of the skin and whites of the eyes.

The treatment for malaria depends upon the geographic area where a person has been infected with the disease. Different areas of the world have malaria types that are resistant to certain medications.

Malaria is a disease which can be transmitted to people of all ages. It is caused by parasites of the species Plasmodium that are spread from person to person through the bites of infected mosquitoes. Malaria is a parasitic disease that involves infection of the red blood cells. Of the four types of malaria, the most serious type is falciparum malaria, which can be life-threatening. The other three types of malaria (vivax, malariae, and ovale) are generally less serious and are not life-threatening. The scientific name of the particular type of mosquito is Anopheles. An infected Anopheles mosquito bites a person and injects the malaria parasites into the blood. The malaria parasites then travel through the bloodstream to the liver and eventually infect the red blood cells.

Causes of Malaria

1. Malaria is usually caused by a mosquito bite and the parasite microbe is passed from the mosquito to the blood through a sharp hypoderme needle like sting. Risk factors include traveling in areas in which such mosquitoes are found or, rarely, being bitten by a mosquito that has previously fed on an “imported” case of malaria (such that the case can occur in an area of the world where malaria is not endemic).

2. Transmitted by transfusion of infected blood.

Symptoms of Malaria

1. Sequential chills, fever, and sweating.

2. Jaundice.

3. Stools, bloody.

4. muscle pain.

5. Anemia.

6. Headache.

7. Nausea and vomiting.

Treatment of Malaria

Prevention of malaria what is practiced in epidemic areas is by spraying insecticides like DDT. Many new drugs are available for malaria, however most of the drugs are derived from Quinine derivatives. Malaria often requires treatment with medicine (antimalarial medications). Most of the time antimalarial medications effectively treat the infection; however, some malaria parasites may survive because they are in the liver or are resistant to the medication.

By: Juliet Cohen Article Directory: http://www.articledashboard.com

Juliet Cohen writes health articles for health care clinic. She also writes articles for women health.

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Malaria is a mosquito-borne disease caused by a parasite, Plasmodium, which infects red blood cells. Infected mosquitoes spread it.

The mosquito infects you through bites so prevention is important

Mosquito Bite treatment

People with malaria frequently experience fever, chills, and flu-like disease. Malaria is a main cause of death worldwide.

Detailed Info on Malaria

Approximately 300 million people worldwide are affected by malaria and between 1 and 1.5 million people die from it every year, but it is almost wiped out in the United States. The disease is frequently a problem in developing countries with warm climates. If you travel to these countries, you are at risk. People get malaria by being bitten by an infective female Anopheles mosquito. Only Anopheles mosquitoes can spread malaria and they must have been contaminated through an earlier blood meal taken on a contaminated being. When a mosquito bites an infected person, a little amount of blood is taken in which contains microscopic malaria parasites. About 1 week later, when the mosquito takes its next blood meal, these parasites mix with the mosquito’s saliva and are injected into the person being bitten. Because the malaria parasite is found in red blood cells of an infected person, malaria can also be transmitted through blood transfusion, organ transplant, or the shared employ of needles or syringes contaminated with blood.

Symptoms of malaria comprise fever, headache, and vomiting. Malaria may reason anemia and jaundice (fair coloring of the skin and eyes) because of the loss of red blood cells. Malaria is not extending from person to person like a cold or the flu, and it cannot be sexually transmitted. You cannot get malaria from casual contact with malaria-infected people, such as sitting next to someone who has malaria. Treatment of malaria involves supportive measures as well as exact anti malarial drugs. Anti-malarial drugs can be prescribed to people traveling to areas where malaria is prevalent.

The types of anti-malarial medications prescribed will rely on the drug-resistance patterns in the areas to be visited. Chloroquine is an often used anti-malarial medication, but quinidine or quinine, or the amalgamation of pyrimethamine and sulfadoxine, are given for chloroquine-resistant infections.

People on anti-malarial medications may still become infected. Prevention is better than cure. Avoid mosquito bites by wearing protective clothing over the arms and legs and using screens on windows. Use of mosquito nets and insect repellents can decrease the chance of getting infected.

By: Juliet Cohen

Article Directory: http://www.articledashboard.com   Juliet Cohen writes articles for beauty blog. She also writes articles for new hairstyles and hairstyles blog.

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Fever, headache, and vomiting are the symptoms of malaria and they normally appear between 10 and 15 days after the mosquito bite. If not treated immediately and rightly, Malaria can be life threatening. 

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While there is no vaccine for malaria, there are antimalaria medications available that can reduce the risk of developing symptoms of the disease. These medications will not provide 100 per cent protection against the disease.

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